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KMID : 0043320120350061003
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Archives of Pharmacal Research
2012 Volume.35 No. 6 p.1003 ~ p.1008
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Anticomplementary activity of oleanane-type triterpenes from the roots of Aceriphyllum rossii
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Min Byung-Sun
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Abstract
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To gain a better understanding of the anticomplement activity of triterpenoids, the complement activity of five unusual oleanane-type triterpenoids, bearing a carboxyl group at the C-29 position, were estimated against the classical pathway of a complementary system. The five triterpenoids were obtained from the roots of Aceriphyllum rossii (Saxifragaceae), and were determined to be aceriphyllic acids B?E (1?4) and K (5). Of the isolated compounds, compounds 1, 2 and 5 showed anticomplement activities, with IC50 values of 328.4, 77.5 and 348.6 μM, respectively, whereas, compounds 3 and 4 were inactive. This showed that a carboxyl group at the C-23 position and an α-configuration of a hydroxyl group at the C-3 position in the olean-29-carboxylic acid triterpenoids seemed to play an important role in the anticomplement activity of human serum against erythrocytes.
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KEYWORD
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Aceriphyllum rossii, Saxifragaceae, Anticomplementary activity, Olean-29-carboxylic acid triterpenoid
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